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Infection and Immunity Zurich

  • Artistic rendering of viruses (red) during uptake into a human cell. The light brown structures depict endosomal vesicles carrying viruses. Image is from the cover of Cell Host Microbe, Vol 18, July issue 2015, and refers to the article by Luisoni et al., same issue p. 75-85).
    Artistic rendering of viruses (red) during uptake into a human cell. The light brown structures depict endosomal vesicles carrying viruses. Image is from the cover of Cell Host Microbe, Vol 18, July issue 2015, and refers to the article by Luisoni et al., same issue p. 75-85).
  • Surface scanning electron micrograph of three human cells (yellow depicting the plasma membrane) on a flat substratum (blue). Note that the cells are connected to each other at regions of cell-cell contacts. The heightened center of each cell depicts the location of the cell nucleus underneath the plasma membrane.
    Surface scanning electron micrograph of three human cells (yellow depicting the plasma membrane) on a flat substratum (blue). Note that the cells are connected to each other at regions of cell-cell contacts. The heightened center of each cell depicts the location of the cell nucleus underneath the plasma membrane.
  • Schematic depiction of a nonenveloped virus (in color) with protruding fibers (light blue) and a capsid (bark blue, with red and yellow capsomers). The virus is artistically positioned above a human cell, depicted in an electron microscoph of a thin section stained with heavy metals. Note the nucleus (dark spherical structure in the cell center) and various lipid vesicles (circular dark lines) in the cytoplasm (light grey).
    Schematic depiction of a nonenveloped virus (in color) with protruding fibers (light blue) and a capsid (bark blue, with red and yellow capsomers). The virus is artistically positioned above a human cell, depicted in an electron microscoph of a thin section stained with heavy metals. Note the nucleus (dark spherical structure in the cell center) and various lipid vesicles (circular dark lines) in the cytoplasm (light grey).
  • Overlay confocal microscopy image of macrophages (blue) infected with tuberculosis vaccine strain Mycobacterium bovis BCG (green). Acidic compartments (lysosomes, phagolysosomes) are stained in red. Co-localization of bacteria with acidic compartments is indicated by yellow.
    Overlay confocal microscopy image of macrophages (blue) infected with tuberculosis vaccine strain Mycobacterium bovis BCG (green). Acidic compartments (lysosomes, phagolysosomes) are stained in red. Co-localization of bacteria with acidic compartments is indicated by yellow.
  • Pipetting scheme for testing synergistic effects of drug candidates. Two-dimensional concentration gradients of two drug candidates are tested for (synergistic) antibacterial activity. Each well contains a unique concentration of two drug candidates. Afterwards wells are inoculated with a bacterial strain and growth is monitored over time. For visualization red and blue dyes instead of drug candidates have been applied.
    Pipetting scheme for testing synergistic effects of drug candidates. Two-dimensional concentration gradients of two drug candidates are tested for (synergistic) antibacterial activity. Each well contains a unique concentration of two drug candidates. Afterwards wells are inoculated with a bacterial strain and growth is monitored over time. For visualization red and blue dyes instead of drug candidates have been applied.
  • The presence of tertiary lymphoid structures (TLS) is an independent, positive prognosticator in non-small cell lung cancer (NSCLC). The image shows a TLS containing a germinal center in a biopsy from a NSCLC patient.
    The presence of tertiary lymphoid structures (TLS) is an independent, positive prognosticator in non-small cell lung cancer (NSCLC). The image shows a TLS containing a germinal center in a biopsy from a NSCLC patient.
  • Tissue section of a salivary gland 4 weeks after infection with murine cytomegalovirus (MCMV). Red: Cell membranes; green: MCMV infected cell; blue: cell nuclei.
    Tissue section of a salivary gland 4 weeks after infection with murine cytomegalovirus (MCMV). Red: Cell membranes; green: MCMV infected cell; blue: cell nuclei.
  • Electron micrograph thin section of a human cell infected with adenoviruses. The virus (dark structure) in the upper part of the image is located on the plasma membrane (thin wavelike line) outside the cell. The virus in the lower part of the image is located in a clathrin-coated endosome (the dark line representing the endosomal membrane, and peripheral spike-like structures in light grey the clathrin coat). The diameter of a virus is about 0.1 micrometer.
    Electron micrograph thin section of a human cell infected with adenoviruses. The virus (dark structure) in the upper part of the image is located on the plasma membrane (thin wavelike line) outside the cell. The virus in the lower part of the image is located in a clathrin-coated endosome (the dark line representing the endosomal membrane, and peripheral spike-like structures in light grey the clathrin coat). The diameter of a virus is about 0.1 micrometer.
  • Artistic impression of a virus (red) in the extracellular medium near a human cell (green-grey).
    Artistic impression of a virus (red) in the extracellular medium near a human cell (green-grey).